Getting older is a part of life. Although we may accept it, very few are thrilled at the thought of aging. As we age, our immune system weakens, we can become slower, feel stiff or pain, our mood, and energy levels change – the list goes on.
Open any magazine or turn on the TV, and you’re bound to see an advertisement for anti-aging creams and serums to make you look younger. These cosmetic anti-aging remedies are just skin-deep, and don’t target the aging that happening on a cellular level. People want to live healthier, happier lives for longer. Despite getting older, we want to age less.
An extensive amount of longevity science has discovered promising therapies that target aging on a much deeper level. For example, there is an increasing amount of scientific literature looking at the potential longevity benefits of metformin. If you, like many others, are hoping to delay the effects of aging, you should consider buying metformin.
Research on Metformin and Anti-Aging
Metformin has many anti-aging benefits. In 2014, a study was conducted in the UK that looked at mortality in individuals with type 2 diabetes. This was a large study as the scientists compared 78,000 individuals with type 2 diabetes to a control group of another 78,000 people without diabetic controls. The individuals with type 2 diabetes were given metformin, and the control group was not. After observing the participants for five years, the results of this study showed that patients with type 2 diabetes whom the researchers gave metformin to had a longer survival rate than the non-diabetic control groups. Therefore, the researchers observed that metformin is associated with lower overall mortality. They concluded, “there may be a prognostic benefit of Metformin prophylaxis in people without diabetes,” meaning metformin may prevent disease in both non-diabetic and diabetic individuals.
Living longer is an essential piece of longevity. When we try to delay aging, we are also trying to prolong our lives. That said, we don’t simply want to see more candles on our birthday cake while being sick and unhappy. People not only want to live longer but want to live happier and healthier lives.
In the previous study, we can see the positive effect metformin can have on those who have type 2 diabetes. Other research has shown that metformin can reduce the risk of developing diabetes altogether. A clinical study entitled Diabetes Prevention Program, was published in The New England Journal of Medicine in 2002. This comprehensive study monitored over 3200 non-diabetic individuals over three years. The trial aimed to see if diet and exercise or metformin could prevent the onset of diabetes. The results of the study found that metformin was able to reduce the risk of developing diabetes by 31%. This was equally effective for both men and women.
In addition to preventing diabetes, metformin also has a positive impact on heart health. In 2009, a randomized, placebo-controlled trial looked at the effects of metformin in 390 patients. More specifically, how it would affect macrovascular disease. This study involved a 4.3-year follow-up. It concluded that metformin lowered macrovascular and cardiovascular risks, reducing macrovascular disease and cardiovascular mortality. This study also showed that metformin can reduce the incidence of cardiovascular events in non-diabetic and diabetic patients with coronary heart disease.
For effective anti-aging therapies, you need to address the source of the aging. This is what metformin does. It triggers biological austerity measures, which relocate limited resources from growth and reproduction to survival. This state shows resistance to age-onset pathologies. Metformin does this by limiting metabolic reactions in the mitochondria. In turn, it slows down the process in which we convert macronutrients to energy. As a result, there is less ATP production which activates AMPK, which then implements these biological austerity measures.
Biological austerity measures include decreased insulin levels, reduced accumulated oxidative damage, induced fatty acid oxidation, the slowing of DNA damage, induced autophagy, and a reduction in chronic inflammation. These measures are how we achieve the longevity benefits seen in the above studies, such as reducing the risk of macrovascular disease and reducing the chance of diabetes.
This research is very telling. Although the FDA has not yet approved metformin for these uses, multiple studies show the anti-aging benefits it has. Metformin is a safe drug with a long history. It is an FDA-approved drug to treat diabetes and has been used for over 60 years with a superior safety record. It is also listed on the World Health Organization’s Model List of Essential Medicines, which is a catalog of the most effective, safe, and cost-effective therapies. Metformin is a pill that is derived from natural compounds in the French Lilac plant. Side-effects are minimal. The most common side-effects of metformin are a reduction in Vitamin B12 (which can be resolved with a B12 supplement) and gastrointestinal discomforts such as nausea, bloating, or diarrhea. You can mitigate these side effects by starting with a smaller dose or using an extended-release version.
Most people would agree that the anti-aging benefits far outweigh the side effects. These anti-aging benefits are the reason you should buy metformin. Thankfully, buying metformin is easy to do. The drug is accessible and affordable and can be purchased online from the comfort of your home. AgelessRx.com, an online telemedicine clinic, specialized in longevity and anti-aging prescription therapies. One of the prescription products they specialize in is metformin. If you are looking to buy metformin, you can visit their website to access their abundance of information, resources, and studies or begin the purchase process. To purchase, simply complete a medical intake form. Following this, you will either receive medical approval or a follow-up. The physician will determine if metformin is suitable for you based on your medical history. Once approved, the medication will be shipped directly to your front door.
We can accept the fact that we will get older each year, but we don’t need to accept declining health or a poorer quality of life. You can take a proactive approach and live a longer, healthier life.